ICD-10-CM Book 2026 Edition

Chapters  /  Chapter 21  /  Z14-Z15  /  Z15
Z15 Genetic susceptibility to disease
Includes confirmed abnormal gene
UseAdditionalCode code, if applicable, for any associated family history of the disease (Z80-Z84)
Excludes1 chromosomal anomalies (Q90-Q99)
Z15.0 Genetic susceptibility to malignant neoplasm
CodeFirst , if applicable, any current malignant neoplasm (C00-C75, C81-C96)
UseAdditionalCode code, if applicable, for any personal history of malignant neoplasm (Z85.-)
Z15.01 Genetic susceptibility to malignant neoplasm of breast
nonPrimary Yes
Z15.02 Genetic susceptibility to malignant neoplasm of ovary
sex Female
nonPrimary Yes
Z15.03 Genetic susceptibility to malignant neoplasm of prostate
sex Male
nonPrimary Yes
Z15.04 Genetic susceptibility to malignant neoplasm of endometrium
sex Female
nonPrimary Yes
Z15.05 Genetic susceptibility to malignant neoplasm of fallopian tube(s)
Z15.06 Genetic susceptibility to malignant neoplasm of digestive system
Z15.060 Genetic susceptibility to colorectal cancer
Z15.068 Genetic susceptibility to other malignant neoplasm of digestive system
Genetic susceptibility to biliary tract cancer
Genetic susceptibility to gastric cancer
Genetic susceptibility to pancreatic cancer
Genetic susceptibility to small bowel cancer
Z15.07 Genetic susceptibility to malignant neoplasm of urinary tract
Z15.09 Genetic susceptibility to other malignant neoplasm
nonPrimary Yes
Z15.1 Genetic susceptibility to epilepsy and neurodevelopmental disorders
CodeAlso , if applicable, related disorders such as:
developmental and epileptic encephalopathy (G93.45)
developmental disorder of speech and language (F80.-)
developmental disorders of scholastic skills (F81.-)
epilepsy, by specific type (G40.-)
intellectual disabilities (F70-F79)
other neurodevelopmental disorder (F88)
pervasive developmental disorders (F84.-)
Z15.2 Genetic susceptibility to obesity
CodeAlso , if applicable, any associated manifestations, such as:
other obesity (E66.8-)
polyphagia (R63.2)
UseAdditionalCode code to identify body mass index (BMI), if known (Z68.-)
Z15.3 Genetic susceptibility to kidney disease
CodeAlso , if applicable, hypertension (I10-I1A)
Z15.8 Genetic susceptibility to other disease
Z15.81 Genetic susceptibility to multiple endocrine neoplasia [MEN]
Excludes1 multiple endocrine neoplasia [MEN] syndromes (E31.2-)
nonPrimary Yes
Z15.89 Genetic susceptibility to other disease
nonPrimary Yes